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Tirzepatide vs semaglutide
Both medicines can support weight loss when prescribed appropriately, but they are not interchangeable. Your prescriber weighs your history, other medicines, side effects and access.
At a glance
- UK information only — not medical advice
- Prescription-only medicines
- Follow your prescriber, pharmacist or nurse
When to get help
- Seek urgent medical help for severe or persistent abdominal pain, especially if it spreads to your back or comes with vomiting.
- Speak to a clinician urgently if vomiting or diarrhoea is persistent or you cannot keep fluids down.
- Call NHS 111 or seek emergency care if you have signs of a serious allergic reaction, sudden vision changes on semaglutide, or any symptom your prescriber told you to treat as urgent.
Always follow your prescriber, pharmacist or nurse. SlimBee does not provide personal medical advice.
Mechanism
Mounjaro activates GIP and GLP-1 receptors; Wegovy activates GLP-1 receptors. Trial averages differ; individual response varies.
Evidence and licensing
Wegovy’s familiar maintenance dose is 2.4mg weekly, but the MHRA has approved use up to a maximum of 7.2mg weekly for adult patients with obesity where clinically appropriate and prescribed. The 7.2mg dose should only be used exactly as directed by a prescriber.
NICE technology appraisals set NHS access criteria; private routes still require clinical assessment.
Medical disclaimer: SlimBee is an independent UK information website. We do not prescribe, dispense or sell medicines. Always follow your prescriber, pharmacist or nurse.